Naringin from grape fruit and supplement regimen methods for modulating the dosing with TMG.

 Note that while naringin is a (CYP) antagonist/inhibitor,

TMG (Tri-Methyl-Glycine) is a (CYP) agonist supporting clearance of certain CYP-targeted substrates.

Therefor. To mitigate overdosing. Using TMG is a good conjunct strategy.


But to avoid a potential nullification or cancelation effect, one could be mindful of the timing of these supplements. Grape fruite consumption say in the morning smoothie.

Note that you do not want to nullify the effect (I don't know if this is what may happen, but in theory it seems plausible), by using too much TMG.

More on TMG here.. TMG blogpost


Followed by avokado, berries, coffee and green tea and some cacao/dark chocolate will give a therapeutic effect of polyphenols.

However the effects comes in two phases. The first phase is when digested in small intestine, absorption, which is maybe just 1% of the bioactives of the polyphenols.

Next phase is from the colon and gut microbiom, several hours later, which will generate secondary beneficial metabolites. This is 99% of the total substrates, and is therefor hypothesised to induce a larger effect, acting via the gut microbiota of the host.  For example epigallactin from certain berries or nuts will, given the right microbiom, produce urilithin A, which have shown benificial effects on human cardiovascular  and endurance performance. 


Note that the consumption of the specific foods have been shown to, over time, actually adapt the microbiom favorably toward the production of these post-probiotic metabolites and therefor it may be a good idea to stick to a certain set of foods over some amount of time to get these beneficial changes/adaptations.

The above is also one more reason to choose foods that are kinder to humans, (my hypothesis),

like berries and fruits, that may be more evolutionary adapted and have less side-effects by being easier to digest than many other plants like certain vegetables. Also fruit and berries have a slightly different polyphenolic profile than vegetables, the effect may be someone different, and perhaps better in the long run?

The above idea is one of my working ideas, and is not necessarily based on any particular study.

It is just an idea that needs to be investigated and explored and tested.

But I think it is an interesting one and it fits in to a theoretical model of evolution and plant-animal co-evolution and ecological balance mechanisms. I enjoy doing these thought experiments.


Kommentarer

Skicka en kommentar

Populära inlägg i den här bloggen

Glutathione

Glutathione   Glutathione  is a tripeptide molecule composed of glutamic acid , cysteine , and glycine . It is one of the most important antioxidants produced by the body and has a wide range of functions. Here are some of the functions of glutathione: 1. Antioxidant : Glutathione is a powerful antioxidant that neutralizes harmful free radicals and reactive oxygen species (ROS) in the body. It protects cells and tissues from oxidative damage caused by environmental toxins, radiation, and other factors. 2. Detoxification : Glutathione plays a crucial role in the detoxification of harmful substances, such as heavy metals, chemicals, and drugs. It binds to toxins and helps to eliminate them from the body. 3. Immune function : Glutathione is essential for proper immune function. It helps to activate immune cells, such as T cells and natural killer cells, which are important for fighting infections and cancer. 4. Protein synthesis : Glutathione is involved in protein synthesis, ...
Läs mer

Constant change and the perception of exploration

  I find that my life is an explorative adventure. I explore not just the external world. But the internal world. I explore the platonic world that could be seen to be outside of both this external and internal world. The platonic world is independent of the internal world. I feel, I should define the building blocks of this thinking out loud monologue to make things less ambiguous. Defining the internal world as the perceived world or mental world. This is more complicated than it may sound.   It is not independent of the external world. The external world being defined as a physical world that exists independent of perception. To some degree this is a philosophical discussion where there is degrees of arbitrarity or bias in the way we reason about this. Us reasoning about is involves cognition and mental processes such as awareness and neurophysiological interaction of the physical external world as input. There are further questions that needs to be considered. Where does t...
Läs mer

Creatine supplementions effect on sleep and brain health

There have been a limited number of studies investigating the effects of creatine supplementation on brain function and sleep, and even fewer studies specifically examining the timing of creatine supplementation with respect to these outcomes. One study published in 2018 investigated the effects of creatine supplementation on sleep quality in healthy young men. Participants received either a placebo or creatine supplements (20 grams per day) for 7 days, and were instructed to take the supplements either in the morning or in the evening. The study found that creatine supplementation did not significantly affect sleep quality, and there were no differences in sleep quality between the morning and evening supplement groups. Another study published in 2020 investigated the effects of creatine supplementation on cognitive function in healthy older adults. Participants received either a placebo or creatine supplements (5 grams per day) for 24 weeks, and were instructed to take the supplement...
Läs mer