More on TMG - Tri-Methyl-Glycine

 Trimethylglycine (TMG) is metabolized in the liver through a process called demethylation, where the three methyl groups are removed to produce glycine. The demethylation of TMG is catalyzed by the enzyme betaine-homocysteine methyltransferase (BHMT), which uses the methyl groups from TMG to convert homocysteine to methionine.

In addition to BHMT, TMG can also be metabolized by the enzyme flavin-containing monooxygenase (FMO), which adds a hydroxyl group to the molecule to produce dimethylglycine (DMG). DMG can then be further metabolized to sarcosine and glycine through a process called glycine cleavage.

The metabolism of TMG and its metabolites involves several enzymes and metabolic pathways, including the methionine cycle, the folate cycle, and the glycine cleavage system. These pathways play important roles in regulating the metabolism of amino acids, methylation reactions, and the detoxification of harmful substances in the body.

It is important to note that the specific metabolism of TMG may vary depending on individual factors such as genetics, dosage, and other medications or supplements being taken concurrently.

TMG metabolism is not affected by (CYP)-modulating polyphenols like naringin from grape fruit. Thus it may a good mitigation strategy if you overtax the (CYP)-enzyme systems.


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