AdLucem

  Trimethylglycine (TMG) is metabolized in the liver through a process called demethylation, where the three methyl groups are removed to produce glycine. The demethylation of TMG is catalyzed by the enzyme betaine-homocysteine methyltransferase (BHMT), which uses the methyl groups from TMG to convert homocysteine to methionine. In addition to BHMT, TMG can also be metabolized by the enzyme flavin-containing monooxygenase (FMO), which adds a hydroxyl group to the molecule to produce dimethylglycine (DMG). DMG can then be further metabolized to sarcosine and glycine through a process called glycine cleavage. The metabolism of TMG and its metabolites involves several enzymes and metabolic pathways, including the methionine cycle, the folate cycle, and the glycine cleavage system. These pathways play important roles in regulating the metabolism of amino acids, methylation reactions, and the detoxification of harmful substances in the body. It is important to note that the specific met...

 Note that while naringin is a (CYP) antagonist/inhibitor, TMG (Tri-Methyl-Glycine) is a (CYP) agonist supporting clearance of certain CYP-targeted substrates. Therefor. To mitigate overdosing. Using TMG is a good conjunct strategy. But to avoid a potential nullification or cancelation effect, one could be mindful of the timing of these supplements. Grape fruite consumption say in the morning smoothie. Note that you do not want to nullify the effect (I don't know if this is what may happen, but in theory it seems plausible), by using too much TMG. More on TMG here..  TMG blogpost Followed by avokado, berries, coffee and green tea and some cacao/dark chocolate will give a therapeutic effect of polyphenols. However the effects comes in two phases. The first phase is when digested in small intestine, absorption, which is maybe just 1% of the bioactives of the polyphenols. Next phase is from the colon and gut microbiom, several hours later, which will generate secondary benefici...

Grape fruit contains an interesting polyphenol called naringin. Naringin , inhibits at least two enzymes in humans called CYP1A2 and  CYP3A4 . The use of this functional food method is to increase beneficial effects of bioactive in from you food and supplements or what you consume during the naringin-induced "open window" time-frame. So beware of what you expose yourself to. Avoid toxic doses of substances of all kinds and focus on foods and supplements with minimal if any side effects. My theory here is to go more with fruit plants than vegetables for this method. Also avoid combining with medication and drugs in particular (like statins etc.. see interaction table).  A good protocol would be to increase the activity of other low level toxicity plants like berries, avocado, olives, moderate amount of coffee etc. Also the timing may play a crucial role here, because of the delay of CYP-metabolism. You should aim to get your coffee and other strong CYP-dependent foods and bev...

My grandmother on my mothers side, bless her soul, knew lots of flowers latin names by heart and worked in her garden when the weather permitted. However, she was not interested in the biology of nutrition and health. This is where I come in. I am. I want to understand how things inter-connect and work and how it can be applied to the human body to achieve better health. Today 2023, in the popular realm of health, there are various trends, as is always the case. However, these trends tends to evolve fast and branch into various extremes more and more. Sometimes, there comes up new interesting ideas that to consider. Often various research is misinterpreted or over-extrapolated etc. Often references to other domains are made with conviction. Like anthropological arguments about what humans have been adapted to eat through evolution and history. While there is some explanatory value in this there is some flaws in reasoning. Like humans have adapted to like eat this or that, therefor it i...

  Terminalia ferdinandiana, also known as the Kakadu plum, is a fruit native to Northern Australia. It is known for its exceptionally high vitamin C content, and it has been used by indigenous Australians for both food and medicinal purposes for thousands of years. The fruit is also a rich source of antioxidants, including gallic acid, which is one of the most potent phenolic compounds found in the fruit.       Kakadu Plum